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Cushing's Disease by: Susan Prince
As our horses enjoy a longer life and many live well into old age so the number of horses with Cushing increases as its more common in older horses especially ponies. It can however affect all breeds and ages. Cushing is caused by an abnormality of the pituitary gland that is situated at the base of the brain. This causes it to produce excessive amount of a hormone called cortisone, which is the body's natural steroid hormone. Signs of Cushing
Over a period of time an affected horse will show some or all of the above signs which are listed. Treatment Within the brain a substance called Dopamine is naturally produce which prevents the over production of hormones. There is another natural substance called Serotorum which has the opposite effect and produces to much cortisone. Treatment will consist of using a drug which mimics Dopamine the most commonly used one is Pergolide which is given in tablet form or using a drug one of the most promising being Trilostane that will block Serotorum. Your vet will decide on which cause of treatment will be most suitable for your horse or pony. Both types of treatment will bring about the same results, keeping the amount of cortisone produce under control. Management The increase in cortisone in the body is similar to the effect of stress so to manage the condition we need to reduce stress levels as much as possible.
Treatment and management will be life-long as there is no cure for the condition. I know from my own experience as I had a old pony called Ringo who suffer with Cushing for many years but still live to the grand old age of 35 that horses can live a comfortable life for many years. The most serious complication is laminitis and this must be manage carefully All the best Sue
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